The physical and mental effects of fentanyl vary depending on how it is used. Fentanyl, an opioid, is available in various forms for both medical and illicit use. It is prescribed to treat severe pain but is also misused and a major contributor to the opioid crisis. Fentanyl is a powerful opioid used for pain control. When prescribing fentanyl, the dose and duration should be the lowest and shortest effective, and the patient is continually assessed for compliance and/or diversion in outpatient settings. Also, consider augmenting the dose of fentanyl as needed.

What Is This Medication?
Fact sheet with facts about fentanyl, including types and forms of fentanyl and signs of overdose with tips on overdose. Overdoses due to fentanyl and its analogues (F/FAs) push naloxone to the limit. How to test your drugs using fentanyl test strips. If you have questions about poisoning from opioids, including fentanyl, contact Poison Control for expert advice.

You also have trouble feeling pleasure from anything besides the drug. Fentanyl may cause other side effects. Avoid drinking alcohol for several hours after you take fentanyl. Because of this, don't drive or do activities that require you to be fully alert and awake after your treatment.
Treating Fentanyl Addiction
Sometimes people freeze fentanyl patches and cut them into smaller portions. Some people take fentanyl illegally by separating it from skin patches and injecting it. Drug enforcers theorize that dyes may help drug traffickers avoid detection with the drugs. Powdered fentanyl can also be pressed into pills that look like prescription pills such as Percocet or Xanax. When it’s in powdered form, it looks a lot like other powdered drugs such as cocaine. Your doctor might prescribe fentanyl if you have severe pain due to cancer, nerve damage, serious injury, or major surgery.

Opioids Have Become A Major Problem In The US, Even If Congress Hasn’t Given It That Much Attention
Like other opioid use disorders, fentanyl addiction is a treatable chronic medical condition. Overdose deaths involving fentanyl among adolescents have risen in recent years, even though teens don’t report taking more illegal drugs. In many cases, people do not know that their drugs are tainted with fentanyl.14 Unless drugs are tested, it is impossible to tell if they have been mixed with fentanyl.15
Medication-assisted treatment (MAT) is one of the most effective approaches for fentanyl addiction. For many people, simply being in a place where they previously used drugs can spark a powerful craving. Fentanyl is often added to street drugs like heroin, cocaine, and counterfeit pills without the buyer's knowledge. While fentanyl is helpful for treating severe pain, it must be handled with extreme care. While it was originally developed for medical purposes—primarily to treat severe pain—it's since become a major player in the illicit drug market.
Why Is It So Dangerous?
Even through the narrow lens of cutting the drug supply, the sellers have already proven adept at adapting to new circumstances. Even as the US worked with China to crack down on one fentanyl compound, the sellers simply tweaked their formula and offered to sell a new version in another email included in the report. It became clear how adaptable the fentanyl sellers were.
- The drug interacts with receptors in your brain to create feelings of pain relief, relaxation, contentment, and pleasure.
- Once you’ve been taking fentanyl for a while, your body gets used to it and stopping can be very hard.
- Alcohol and other drugs (ie, cocaine, heroin) can synergistically exacerbate fentanyl's side effects, creating multi-layered clinical scenarios that can be complex to manage.
- If a person has a susceptibility to addiction, then it is a situation where the person is more likely to develop a substance use disorder.
- According to the National Association of Boards of Pharmacy, nearly 95% of websites offering prescription-only drugs online operate illegally.
Naloxone: Overdose Reversal Drug
Fentanyl is much more potent than other opioids like morphine or heroin. Like other opioids, fentanyl can ease pain and make a person feel happy and relaxed. Illegally made fentanyl is now a main driver of the overdose and addiction crisis in the United States.4
FIND TREATMENT:
Most of the new laws are designed to increase penalties for fentanyl-related crimes and raise awareness about addiction and the risk of counterfeit pills and fentanyl-contaminated drugs. Powdered fentanyl is typically mixed with other street drugs or pressed into fake pills that look like legitimate medications or brightly colored candy. Jon Zibbell, a public-health analyst at RTI International, said that the sale of many different types of fentanyl can increase the risk of overdose.
What If I Miss A Dose?
A healthcare provider will give you an injection of Fentanyl in a hospital or clinic. The street version of the drug is primarily pressed into pill form, typically to mimic the look of other legitimate opioid pills. Fentanyl is a synthetic opioid that’s at least 50 times more powerful than morphine.
- Opioid medication enters the brain and binds to opioid receptors, restricting pain signals and causing relaxation (Oesterle, 2021).
- Keep track of how much fentanyl is left so you will know if any is missing.
- He progressed to prescription painkillers, and then, when they became too expensive, to heroin.
- Fentanyl can be made into pills or powders, which can unknowingly get mixed into other drugs.
- Food and Drug Administration (FDA) for the treatment of opioid use disorder.
Professional treatment centers provide the medical care, therapy, and ongoing support you need to build a healthy, fentanyl-free life. It works by binding to opioid receptors and blocking fentanyl's effects—essentially hitting pause on an overdose and giving someone a chance to get emergency help. But for the people using these drugs, it creates a high-risk gamble where even a trusted source or familiar dose could suddenly turn deadly.
OUDs are chronic but treatable medical conditions that involve changes in our brains, which makes stopping very difficult without support. Learn more about naloxone. According to the Drug Enforcement Administration, 2 mg of fentanyl (which can fit on the tip of a pencil) can be enough to kill the average American. Zawilska JB, Kuczyńska K, Kosmal W, Markiewicz K, Adamowicz P. Carfentanil – from an animal anesthetic to a deadly illicit drug. Lötsch J, Walter C, Parnham MJ, Oertel BG, Geisslinger G. Pharmacokinetics of non-intravenous formulations of fentanyl. DEA warns of brightly-colored fentanyl used to target young Americans.
The American Medical Association and state boards of medicine and pharmacy have all condemned the practice of cyber doctors issuing online prescriptions as unacceptable medical care. Despite the lifesaving track records of these medications, their availability is limited by restrictions on where and how they can be used and inadequate numbers of prescribers. For those taking fentanyl in nonmedical settings, there is no medical team available to monitor someone’s breathing rate in real time to ensure their safety. My colleagues and I choose fentanyl when patients need immediate pain relief or sedation, such as anesthesia for surgery. As a result, it is much more profitable to cut a kilogram of fentanyl compared to a kilogram of heroin. Fentanyl is both sold alone and often used as an adulterant because its high potency allows dealers to traffic smaller quantities but maintain the drug effects buyers expect.

Learn more about law enforcement and overdose response here. Fentanyl is unlikely to become aerosolized and cause overdose Any opioid pill not from a pharmacy is highly likely to be fake and contain fentanyl. Fentanyl and related drugs are made and sold illicitly on the street or online. There are pharmaceutical forms of fentanyl that are used for anesthesia and pain. They can be used to test injectable drugs, powders, and pills.
In this article, we will provide an overview of where you can legally purchase fentanyl. Get the in-person or virtual care you need. Need a primary care doctor or a specialist?
What May Interact With This Medication?

Parents can face charges if their children ingest other drugs, but the potency of opioids dramatically increases the risk of accidental fatal overdose in small children. Researchers say the internet is a surprisingly common method of obtaining fentanyl, an opioid that is now responsible for more overdose deaths than heroin or prescription painkillers. The Centers for Disease Control and Prevention (CDC) is informing public health officials, clinicians, and affected patients, their families, and caregivers about a potential public health risk among individuals ordering what they believe to be prescription medications from online pharmacies. While it has legitimate medical uses, illicitly created fentanyl has become the dominant opioid on the U.S. drug market, and it fueled an overdose crisis that surged in Colorado and across the rest of the United States. Implications for overdose prevention and initiating treatment with medications for opioid use disorder are described. The FDA has approved these antidote medications for emergency treatment of patients with known or suspected opioid overdose experiencing respiratory and/or central nervous system (CNS) depression.