Even if the test is negative, take caution as test strips might not detect more potent fentanyl-like drugs, like carfentanil.6 Drugs mixed with fentanyl are extremely dangerous, and many people may be unaware that their drugs contain it. When people overdose on fentanyl, their breathing can slow or stop. Medications for opioid addiction work on the brain by interacting with the same receptors that opioids affect and causing different effects. Mixing fentanyl with any drug is risky, but some drugs pose a serious danger if you take them alongside fentanyl.
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- An opioid drug antagonist such as naloxone can help to correct OIRD symptoms.
- Key signs of an opioid overdose include coma, pinpoint pupils, and slow or difficult breathing.
- Blood or plasma fentanyl concentrations are expected to be in a range of 0.3–3.0 μg/L in persons using the medication therapeutically, 1–10 μg/L in intoxicated people, and 3–300 μg/L in victims of acute overdosage.
- Fentanyl is a very powerful synthetic opioid.
Subcutaneous administration often causes pain due but a bicarbonate solution exists which does not cause pain when giving subcutaneously. In horses at analgesic doses tachycardia, restlessness, and excitement occur. Fentanyl is less common and has more adverse effects in livestock and equine compared to cats and dogs. Due to fentanyl's short duration and quick onset it is commonly used as a constant rate infusion or as a transdermal patch, with the latter being able to last 3 to 4 days. The Russian Health Minister later stated that the gas was based on fentanyl, but the exact chemical agent has not been clearly identified.
What Are The Signs Of Fentanyl Overdose?
Even a small dose of fentanyl can cause a fatal overdose. When a person takes a higher fentanyl dose than their body can handle (an overdose), their breathing can slow to a life-threatening level.8 See “What is an overdose? When used as prescribed, it is also very effective in treating cancer pain or other types of severe chronic pain that don’t respond to other pain medicines.1,2,3 Read more about opioids on the NIDA website.
Symptoms Of Overdose May Include The Following:

The DEA has found an average of 2.4 milligrams of fentanyl in the pills they test (DEA, 2024). Fentanyl can be illegally mixed into other substances, including heroin, cocaine, ecstasy, and methamphetamine (NIDA, 2021). Fentanyl is 100 times stronger than morphine and 50 times stronger than heroin (DEA, n.d.).
Harm Reduction Needs You Join The Movement
This regulatory gap enables brokers to evade detection, seamlessly navigating between the legal chemical trade and the illicit drug market to acquire the necessary precursors. The fentanyl supply chain in Mexico consists of a vast and elusive network, potentially involving hundreds of players. Some heroin dealers mix fentanyl powder with heroin to increase potency or compensate for low-quality heroin.